A Feedforward Loop Links Gaucher and Parkinson's Diseases?
نویسنده
چکیده
Mutations in the GBA gene that encodes glucocerebrosidase cause the lysosomal storage disorder Gaucher disease but also increase the risk for Parkinson's disease. Mazzulli et al. (2011) uncover a possible mechanism to explain this connection: loss of glucocerebrosidase creates a positive feedback loop of reduced lysosomal function and α-synuclein accumulation, ultimately leading to neurodegeneration.
منابع مشابه
Looping the link between Gaucher and Parkinson's disease.
1. Galvin JE, Lee VM, Trojanowski JQ. Synucleinopathies: clinical and pathological implications. Arch Neurol 2001: 58 (2): 186–190. 2. Mazzulli JR, Xu YH, Sun Y et al. Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell 2011: 146 (1): 37–52. 3. Cookson MR. A feedforward loop links Gaucher and Parkinson’s diseases? Cell 2011: 146 (1)...
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ورودعنوان ژورنال:
- Cell
دوره 146 شماره
صفحات -
تاریخ انتشار 2011